bbin游戏

2019學術論壇之十六—氮雜卡賓催化的新型活化模式及功能分子綠色高效構建
2019-04-21 10:53   審覈人:

 

bbin游戏2019學術論壇之十六

 

題目:Carbene Organic Catalysis: New Activation Modes and Rapid Synthesis of Functional Molecules(氮雜卡賓催化的新型活化模式及功能分子綠色高效構建)

報告人: 池永貴教授(南洋理工大學, 貴州大學,長江學者)

時間:  2019年4月23日10:00-11:30

地點:  理學實驗樓409

 

摘要: The Chi laboratory is committed to the state-of-art original chemistry research that addresses problems of both fundamental and practical significance. A key objective is to develop green and efficient synthetic methods to make functional molecules, and to understand the principles guiding the bong breaking and formation events. We focus on the development of fundamentally novel basic catalytic activation modes with useful synthetic applications for the preparation of pharmaceuticals, agriculture chemicals, fine chemicals, and for efficient assembly and/or modification of polymers, biomolecules, and other functional molecules. Over the past years, we have developed new activation modes and synthetic transformations enabled by N-Heterocyclic Carbene (NHC) as the key organic catalyst. Immediate applications of my lab’s new catalytic approaches include concise and green processes for bioactive molecules such as valuable non-natural amino acids and their derivatives. On the fundamental side, our research has created new understanding of chemical reactivities and new concept on catalytic activations. The lab has also taken serous efforts on collaborative development on bioactive molecules and functional materials, and applied research for innovation and entrepreneurship. Examples of the lab’s research include: (a) NHC organic catalyst-enabled activation of carboxylic esters, including activation of the inert beta-sp3-carbon of saturated esters. (b) Biomimetic single-electron-transfer (SET) radical reactions enabled by NHC catalysts. (c) Oxidative NHC catalysis and reaction controls of aldehydes,

including remote-carbon functionalization. (d) Cooperative catalysis merging NHCs with other catalysts. (e) Rapid synthesis functional molecules, including concise asymmetric total synthesis of complex natural products. (f) Multi-disciplinary collaborative research, and application-driven research for innovation and

entrepreneurship.

報告人簡介:池永貴,貴州大學特聘教授,博導,教育部長江學者;新加坡南洋理工大學終身教授,正教授。研究領域涵蓋有機催化,綠色有機合成,醫藥農藥分子的研發及產業化;有機化學與功能材料,有機合成與化學生物學等的跨學科交叉領域的研究。在國內外(中國,新加坡,意大利)領銜開展了數十個由政府及企業資助的研發項目。以通訊作者在Nature Chemistry,J. Am. Chem. Soc.,Nature Commun.,Angew. Chem. Int. Ed.等國際權威刊物刊物上發表SCI論文90餘篇,申請專利多項。獲得了葛蘭素史克和新加坡經濟發展局綠色藥物生產獎、亞洲核心化學講座獎、新加坡傑出青年科學家獎、Thieme雜誌的青年學者獎、新加坡國立研究基金會傑出科學家獎、新加坡南洋研究獎、美國Aldrich公司-耶魯大學聯合講座獎、日本化學會講座獎,日本東京化成工業株式會社-新加坡化學學會工業合成化學獎,中國僑界貢獻獎一等獎等。先後入選新加坡國立基金會Fellow, Investigator, 中國教育部長江學者,科技部中青年創新領軍人才,國家萬人計劃,貴州省十層次人才重點培養專家等。

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